Homeostasis Within the Nervous System

Homeostasis Within the Nervous System Section one Homeostasis is the condition of equilibrium in the body’s internal environment due to the consistent interaction of the body’s main regulatory processes (Tortora and Derrickson, 2009). This process developed by Claude Bernard in 1865 and then named by Walter Cannon in 1926, is used by the endocrine and nervous system in order to maintain a psychological internal environment disregarding external influences. As the environment is always changing the body is constantly trying to regulate factors within it such as water concentration, PH levels, Oxygen levels, nutrients, urea and levels of salt, sugar and electrolytes. During homeostatic regulation the body uses negative feedback to move the body back to within its normal range of values. To do this a receptor detects and responds to a stimuli from the internal or external environment , once detected the receptor sends information of the stimuli down the afferent pathway to a controller. Once received the controller then determines an appropriate response to the stimuli and sends a signal down the efferent pathway to the effector. Once received the effector then makes a change in order to balance out the effects of the stimuli and once again create a dynamic equilibrium within the body. Body temperature is regulated by the autonomic nervous system. Once body temperature rises above the norm it stimulates temperature receptors in the skin dermis, information regarding this change is then sent to the controller which in this instance is the hypothalamus within the brain. The hypothalamus then processes the information and sends a signal to the effect or to start the process of negative feedback. The effector responds by starting the process of vasodilation which in this case would cause the sweat gland to activate in order to lower the body’s core temperature. Without homeostasis a homeostatic imbalance could occur, organisms need to be able to maintain nearly constant internal environments in order to survive grow and function properly (Guyton and Hall, 2006). Enzymes within the body operate to their full potential within a specific range of conditions. By maintaining PH levels and body temperature enzyme linked reactions can occur efficiently. By maintaining changes in water potential homeostasis protects essential cells needed for processes within the body. Changes in water potential could possibly affect the amount of water within tissue fluid and cells, this could potentially cause the cells to desiccate or burst. Therefore, failure to maintain this could possibly lead to a positive feedback mechanism taking over and the possibility of further complications or death. Section 2 The endocrine system consists of glands that are present throughout the body and secrete hormones in order to control actions that maintain homeostasis, preparing the body for the process of fight or flight, controlling growth and controlling sexual development and reproduction. The glands which make up the endocrine system are the hypothalamus, pituitary, thyroid, parathyroid, adrenals, the islet of Langerhans in the pancreas, pineal, the ovaries and testes. Hormones are chemical messengers that are released into the bloodstream; they are carried within blood plasma and affect target cells. Target cells have receptors that attach to specific hormones which have their own receptor. The hormones that are secreted are slower acting however are long-lasting and are good for assisting in areas within the internal environment that require constant adjustments. Therefore assisting with homeostasis. Glucose enters the blood from the small intestine, the body’s blood glucose levels are monitored by a gland called the Islet of Langerhans which is located within the pancreas. A bodies normal range of blood glucose levels are between 4-8mmol/l, these levels frequently change due to eating and exercise. A stable blood glucose level is important within the internal environment as it provides the brain with a strong energy source to enable it to operate and also enables mitochondria to produce Adenosine Triphosphate which is used by cells to perform some of the body’s most important functions such as respiration. Homeostatic regulation of glucose happens when the pancreas detects that the glucose levels become too high or too low as blood passes through it. In the event of Hypoglycemia, where the glucose levels becoming too low the receptor, that is found on the surface of alpha cells within the pancreas stop the production of insulin and start to produce a controller, th e hormone glucagon. Glucagon then stimulates the stores of glycogen in the liver and muscles to convert back to glucose, this process is called glycogenesis. If this is not enough to bring the sugar levels back to normal, glucagon begins to convert fatty acids in to glucose using a process called Gluconeogenesiswithin the effectors. The effectors in this situation are the liver cells, muscles cells and fatty cells. Once converted the glucose is then released into the blood stream causing the bodies glucose levels to rise. In addition to this process, during periods of intense exercise where glucose levels drop the hormone adrenaline will convert glycogen into glucose. In the event of Hyperglycemia, where glucose levels become too high, the receptor which is located on the surface of the beta cells within the pancreas produce a controller to counter act the effects. The controller in this instance is a hormone called insulin. Once insulin is secreted into the bloodstream, glucose lev els within the body decrease because the excess glucose is converted into glycogen through a process called Glycogenesis within the effectors, namely the liver cells and muscles cells. Section 3 Within the process of homeostasis the nervous system detects and responds to adaptions within the body’s internal and external environments by sending fast electrical impulses through nerves to the brain which instructs an effector and enables them to react quickly and return the body to a state of equilibrium. The nervous system consists of the central nervous system which is subdivided into the spinal cord and the brain and the peripheral nervous system which is subdivided into the somatic nervous system which controls our voluntary muscles and the autonomic nervous system which controls our involuntary muscles which helps to create homeostatic regulation of functions within the body such as heart rate. Nerves within these subdivisions transport impulses between the central nervous system and the body. Blood pressure is the force applied on the inner walls of the blood vessels within the body by blood. Blood pressureis measured in millimeters of mercury (mmHg), A blood press ure reading below 130/80mmHg is considered to be normal (NHS Choices) The first numerical factor within a blood pressure reading is the systolic pressure of the blood which is the amount of beats you heart makes per minutes to pump blood away from the heart. The second numerical factor refers to the diastolic pressure which is the pressure of the blood when tour heart is at rest, in-between beats. During homeostatic regulation of blood pressure if a baroreceptor located in the aortic arch and internal carotid arteries detects a decrease in blood pressure it will send fewer impulses to the controllers, the cardiac centre and the vasomotor centre located in the medulla oblongata of the brain simultaneously. By sending fewer impulses to the cardiac centre it excites the sympathetic impulses and inhibits the parasympathetic impulses. This process excites the effector, Sino-atrial node in order to increase the heart rate, by doing this it causes the hearts cardiac output to increase. Alo ngside this process the fewer impulses being sent to the controller, the vasomotor centre also excites the sympathetic impulses which cause the effector, the smooth muscle within the arterioles to constrict this results in vasoconstriction and increased peripheral resistance. The combinations of these processes cause the blood pressure to increase back to within a normal range. During the detection of high blood pressure by the baroreceptors it sends more impulses to the controllers, the cardiac centre and the vasomotor centre simultaneously. By sending decreasing impulses to the cardiac centre it decreases sympathetic input and an increase in parasympathetic input which decreases the heart rate and cardiac output. Alongside this process the increase in impulses to the vasomotor centre causes an effector, the smooth muscle in the arterioles to dilate. This results in vasodilation and peripheral resistance decreases causing blood pressure to decrease. In addition to the baroreceptors , the kidneys are also involved in the monitoring of blood pressure. If blood pressure decreases the kidneys release a hormone called renin that caused the adrenal cortex to release aldosterone. The release of aldosterone causes the kidneys to retain sodium and allows water to flow without resistance causing blood volume and pressure to rise. Section 4 Nephrotic syndrome tends to affect primary school age children. Between two and four children in every 100,000 develop nephrotic syndrome (NHS GOSH) Nephrotic syndrome is a condition where the glomeruli leak a substantial amount of protein therefore not enough protein remains in the blood to enable it to soak up water. This causes the water to move into body tissues causing oedema which presents itself as severe swelling. Proteins provide the body with antibodies this can cause a child with nephrotic syndrome to have a low immune system which results in an increased risk of infection. Other complications of this condition is difficulties in growth and development and prone to blood clots. If protein continues to leak this can lead to a loss of kidney function and ultimately kidney failure. A treatment option for this condition is a medication called furosemide, a loop diuretic that obstructs the reabsorption of sodium and water in the ascending loop of hele, achieved through competitive inhibition. This causes the osmotic gradient through the nephron to be destroyed due to the lumen becoming more hypertonic. This enables the kidn ey to secrete sodium onto the collecting ducts, attracting water volume which is then excreted by the bladder by producing more urine. This will result in less water retention in tissue that would be putting pressure on organs such as the lungs. The Electronic Medicines Compendium States that the pharmacodynamics properties of Furosemide are, it promotes sodium and chloride reabsorption. Furosemide inhibits mechanisms in the epithelial cells in order for sodium and chloride to enter and is transported through the secretory pathway in the proximal tubule. It decreases renal excretion of uric acid and increases loss of potassium in the urine and excretion of ammonia by the kidney. The dosages available for children with oedema as stated by the BNF for Children are orally. Neonate 0.5–2mg/kg every 12–24 hours (every 24 hours if corrected gestational age under 31 weeks),Child 1 month–12 years 0.5–2mg/kg 2–3 times daily (every 24 hours if corrected gestational age under 31 weeks); higher doses may be required in resistant oedema; max. 12mg/kg daily, not to exceed 80mg daily, Child 12–18 years 20–40mg daily, increased in resistant oedema to 80–120mg daily. Through a slow intravenous injection, Neonate 0.5–1mg/kg every 12–24 hours (every 24 hours if corrected gestational age under 31 weeks), Child 1 month–12 years 0.5–1mg/kg repeated every 8 hours as necessary; max. 2mg/kg (max. 40mg) every 8 hours and a Child 12–18 years 20–40mg repeated every 8 hours as necessary; higher doses may be required in resistant cases Through a continuous intravenous infusion ,Child 1 month–18 years 0.1–2mg/kg/hour (following cardiac surgery, initially 100micrograms/kg/hour, doubled every 2 hours until urine output exceeds 1mL/kg/hour) The Pharmacokinetic properties as stated by the Electronic Medicine Compendium of Furosemide are that it is a weak carboxylic acid which exists in the gastro-intestinal tract. Furosemide is rapidly absorbed but 60-70% id absorbed on oral administration within the upper duodenum at PH level 5.0. Furosemide binds to albumin proteins and the volume of distribution ranges between 170 – 270 ml/Kg. 69-97% is excreted in the first four hours after the drug is given and 80-90% of Furosemide is excreted through the kidneys. Reference list Tortora, G.T. and Derrickson, B.H. (2009) Principles of Anatomy and Physiology: Organisation, Support, Movement, and Control Systems of the Human Body. 12th ed. Asia: John Wiley and Sons. Guyton, A.C. and Hall, J.E. (2010) Textbook of Medical Physiology. 12th ed. Philadelphia: Saunders Elsevier Inc. NHS Choices (2014) High Blood Pressure Available from: http://www.nhs.uk/conditions/Blood-pressure-(high)/Pages/Introduction.aspx [Accessed 19.11.2014]. NHS GOSH (2012) Childhood nephrotic syndrome information Available from: http://www.nhs.uk/Conditions/nephrotic-syndrome/Pages/Introduction.aspx [Accessed 22.11.2014] BNF for Children (2014-2015) FUROSEMIDE Available from: https://www.medicinescomplete.com/mc/bnfc/current/PHP11437-lasix.htm?q=furosemidet=searchss=textp=3#PHP11437-lasix [Accessed 23.11.2014] Electronic Medicine Compendium (2014) Furosemide 10mg/ml Solution for Injection or Infusion, 20mg in 2ml and 250mg in 25ml Available from: https://www.medicines.org.uk/emc/medicine/20958 [Accessed 23.11.2014]

Samsung Company

Introduction to Business Samsung Company From a small export business created in Daegu, Korea, Samsung has grown and become one of the world’s leader in the electronics industry. The main specialization of Samsung is digital appliances and media, semiconductors, memory and system integration. The market segmentation of Samsung is giving them a firm commercial advantage. Samsung is segmented according to demographic segmentation, that consists of dividing the market in groups based on different criteria.The most important criterias used by this company is age, income and occupation. Using this criteria they tend to become a leader in technology market as they offer products for each group of customers. Also they are using psychographic segmentation that is the science used to better understand consumers, according to their lifestyle, personality and the main values they have.Another process used by this company is Positive market segmentation that consists of studying the rival goods that are demanded in the market and to compare the quality and price, to understand what the customers need and what products could they insert in the market to satisfy the customer and to increase the confidence of customers in the company. This strategy is one of the strengths of the company as they study the activity of Apple Corporation and other rivals.Using the collected datas they know better what kind of products could they offer to different groups of consumers. The motto of the company is â€Å"Inspire the World, Create the Future†, from it we can deduce that the main purpose for them is to satisfy the customers desires and to achieve a high revenue. Another strength that keeps Samsung in the top world’s brands is the fact that Samsung is totally dedicated to give their customers a wealth of opportunities to rich their full potential. The globalization process for Samsung’s technology businesses started in the early 1980s.So they became a part o f The digital age that has brought new changes and opportunities to global business and Samsung has responded with competitive products and constant innovation. This can be proved by studying the worldwide demand for different goods. For example the worldwide demand for mobile phones was staggering 1. 5 billions in 2011, Samsung accounted for 330 million of those units. This proves the strength of the company as a worldwide leader for different goods as notebooks, mobile phones or digital cameras.Investing directly in activity that spurs economic growth helps Samsung to achieve greater income potential and maintain Samsung brand as one of the most popular in the world. Their position in the market gives them the opportunity to achieve new heights, one of them is their plan of reaching $400 billion in revenue and become one of the world’s top five brands by 2020. Samsung’s Chairman Lee considers that Globalization is the key for future growth, using this idea he created a new strategy to accelerate Samsung’s globalization through developing a pool of global managers as strategic advisors for Samsung Group.Samsung strategies varies for each trade market. In India their strategy is to be a nationwide distributor and retail presence in the domestic consumer durables market. Also they use different advertising tactics to promote their products, for example Samsung has been associated with the Lakme India Fashion Week for its Mobile Phones. The company used this platform in 2005 to launch a new version of mobile phone the D-500, that became after World’s best mobile phone in the Indiam market.Another strategy is the strategic alliances between Samsung and other worldwide recognized organisations, for example in 2007, Samsung established a joint venture with Limo for developing a Linux platform, also they Co-developed for handsets and DVB-H standardization solutions with Nokia. Samsung is also investing money in different companies that co uld help them to provide better technology to consumers, for example investments in shares of US based firm specializing in HDD technology (Integral Peripherals), or investments in operator of telecomunications systems in Chile (Entel).Other strengths of Samsung are the design, effective advertisement and market communication, an actively coming out with newer models and branding as Samsung is ranked 17th among global companies in 2011. A strong point for Samsung is that consists from various business units, the most important is Electronic Industry the one that brings the most revenue for the group (65% in 2011), Engineering and Heavy Industry and Financial Services.When Samsung Electronics rushed its first smartphone to market as a response to the debut of the Apple iPhone, some customers burned the product on the streets or hammered in to the bits in public displays of disaffection. Complaints ranged from dropped calls and heavy touchscreen to frequent auto-rebooting and a lack o f applications. This is weakness for Samsung that they can not keep up with the innovations from Apple and other rivals, even if they try to show the opposite.The biggest threat for Samsung is the global patent battle, between them and Apple,as Apple considers that Samsung copied its iPad and iPhone. Another threat is the fact that Samsung created a big variety of phones into the market so that could lead to a decrease in the demand for new goods in future. Samsung has a different market approach as it offers to customers a much bigger diversity of products. As their previous accomplishments, they look further to explore and develop new activities, as health, medicine, biotechnology. References 1.Kim Youngsoo, 1997, â€Å"Technological Capabilities and Samsung Electronics† 2. Bloom Martin, 1992, „Technological Changes in the Korean Electronics Industryâ€Å" 3. Yu Sengjae, 1989, „Korean Electronics Enterprises : Growth and Strategiesâ€Å" 4. Samsung Global Stra tegy – http://sgsg. samsung. com/Introducing_Samsung_GSG_final. pdf 5. Samsung Business Review -http://www. samsung. com/uk/aboutsamsung/corporateprofile/download/2011_4_Business_Overview. pdf 6. Samsung Financial Highlights – http://www. samsung. com/hk_en/aboutsamsung/corporateprofile/ourperformance/samsungprofile. html

The apocalypse

I was on Brewers lane when I heard a slight whisper over here† I scanned the area, the area where only yesterday me and my mates were chilling, took another glance. Stood there is the mist was my best mate Joana. He was shocked at seeing me, shocked that Vive been walking about the streets fine and haven't encountered any of them things. â€Å"Haven't you seen any things†. My heart thudded. â€Å"What things†. Knew at that point we were in something big together, I couldn't lose him, and we've been best mates since first school.As I said that I saw a dark staggered shadow eve across the back of the churchyard. It moved with such jolt, instantly panicked and froze on the spot. It was like something out of the movies, like something that shouldn't be real. Like something that couldn't be real. Me and Joana went to explore the churchyard to see what this was, as it was the only life we have seen today. We opened the gates the hinges squealed as we pushed to gate to. We stumbled down the pathway, legs like jelly, a place that would normally be so calm, was now so terrifying. Let the bitter saltiness of the sweat that dripped down from my forehead rolled over me eyebrow down my cheek and dribbled into my mouth. The gargoyles on the church seemed as if they were real and were about to pounce on you. Every gravestone glistened; it was as if all the people buried were stood up like an army in formation replacing the gravestones. All the flowers were dead and rotting, there was no color in sight. Just the dark grey of the church and the mellow green tinge of the trees.I heard a wild growl from round the shaded corner, mine and Jonahs hearts started pumping, and we turned around to and got ready to sprint. We took one last look and this demonic shadow was running around the corner except this wasn't no shadow it was what we call walkers of TV programmer and games. I looked at its face; flesh was hanging off around its cheek, I could see inside its eye s the whole eye was white with a hint of grey. Blood around its mouth and teeth were rotten and yellow.

Descriptive Essay - Original Writing - 1483 Words

Colors are flashing. Faint sounds fill the air. Everything’s a blur, like it’s being swept up by the wind. I try to find my footing and stand up, but I just fall back down again. I try to grasp onto my last memories, searching for answers. The only memory I find is my name. Shailene Fonder. When my vision returns back to normal, I see that I am sitting on the greenest patch of grass. When I look around, I see that it is my own front yard, yet I don’t remember my life before the blur. I see trees, my tan house and other houses, almost identical. The same colors and shape, one a duplicate of the next. This time when I stand up, I am stable. Dazed, but stable. Under me are the letters DHE made out of a darker color of grass than the grass†¦show more content†¦I am skinny and suddenly very hungry. I am wearing white ankle length pants. They come together with my black shoes that again have the DHE on them. A matching white coat is upon my torso along with a tight black shirt. I don t own these. I’d would have never worn them. The kitchen is grand. All china plates and bowls accompanied by sterling silverware. They almost seem fictitious. I search for food and a drink of any kind. I sit down with warmed up pizza that I had microwaved before, and a soft drink. The food immediately makes me feel better and the liquid fizzes down my throat. I let out a big sigh and my stomach is contented with the pizza. After I eat and have the astonishing soda, I go back upstairs into the room that I lived in. In the closet in the room, I grab some clothes. I change into athletic pants and a long sleeve shirt. They seem to fit me better. The stairs creak as I go down each step and into the den. It was almost an instinct to grab the weapons. The den walls were filled with them, all different kinds. A long silver knife and a bow and arrow get stuffed into a leather bag. I’d love to get some answers to my many questions so I start exploring. I’m only one step out the door when I hear the sound of a machine. The screeching sound of metal grinding against metal. I look over and see a piece of the wall flip and in it’s place is a picture. A picture of people similar looking to me, but all dead. Chopped off heads, many broken bones,